Milica M Janković, Vera Miler Jerković, Ana Koljević Marković, Dejan B Popović

DOI Number
First page
Last page


The aim of our research was to develop an algorithm for estimation and visualisation of radiopharmaceutical uptake based on time-activity-curve (TAC) analysis in small regions of interest (ROI) in scintigraphic studies. The algorithm is implemented in Labview environment (National Instruments, Texas, Austin) and comprises the following steps: 1) delineation of grid of small ROIs over the examined tissue and corresponding TAC processing; 2) background vs tissue separation; 3) the extraction of all “suspected“ ROIs where TACs are not exponentially descendent; 4) correlation analysis between a TAC corresponding to the suspicious lesion ROI and TACs of neghboring ROIs; 5) the extraction of representative TAC for “suspected“ area by Principal Component Analysis technique; and 6) visual interpretation of radiopharmaceutical distribution in the “suspected“ area. The application of algorithm is presented in data recorded in case of histopathologically proven parathyroid tumors.


uptake, time activity curve, Principal Component Analysis, parathyroid tumor

Full Text:



M. M. Janković, V. Miler Jerković, A. Koljević Marković and D. B. Popović, "Algorithm for the uptake assessment in small lesions in dynamic scintigraphy ", In Proceedings of the 58th ETRAN Conference, 25 June, Vrnjačka Banja, 2014, pp. ME 1.1 1-4 [In Serbian].

D. Fuster, S. Vidal-Sicart, T. José-Vicente, P. Paredes, D. Rubello and F. Pons, "What is the role of preoperative scintigraphic imaging and the intraoperative gamma probe in secondary hyperparathyroidism?" Nucl Med Commun, vol. 35, no. 5, pp. 443-445, 2014.

I. Stoffels, M. Müller, M.H. Geisel, J. Leyh, T. Pöppel, D. Schadendorf and J. Klode, "Cost-effectiveness of preoperative SPECT/CT combined with lymphoscintigraphy vs. lymphoscintigraphy for sentinel lymph node excision in patients with cutaneous malignant melanoma", Eur J Nucl Med Mol, [Epub ahead of print] 2014.

M. Ibusuki, Y. Yamamoto, T. Kawasoe, S. Shiraishi, S. Tomiguchi, Y. Yamashita, Y. Honda, K. Iyama and H. Iwase, "Potential advantage of preoperative three-dimensional mapping of sentinel nodes in breast cancer by a hybrid single photon emission CT (SPECT)/CT system", Surg Oncol, vol. 19, no. 2, pp. 8894, 2010.

M. Giuliano, S.A. Gulec, D. Rubello, G. Boni, M. Puccini, M.R. Pelizzo, G. Manca, D. Casara, G. Sotti, P. Erba, D. Volterrani and A.E. Giuliano, "Preoperative localization and radioguided parathyroid surgery", J Nucl Med, vol. 44, no. 9, pp. 1443-1458, 2003.

A. Koljević Marković, M. M. Janković, I. Marković, G. Pupić, R. Džodić and A. B. Delaloye, "Parathyroid dual tracer subtraction scintigraphy: small regions method for quantitative assessment of parathyroid adenoma uptake", Ann Nucl Med, vol. 28, pp. 736-745, 2014.

M. Đurović M, M. M. Janković and A. Koljević Marković, " Semi-automatic localization of parathyroid tumors in dynamic sestamibi scintigrams ", In Proceedings of the 22nd Telecommunications forum TELFOR 2014, 25-27 November, Belgrade, 2014, pp. 955-958 [In Serbian].

M. M. Janković, " Computer system for acquiring, storing, retrieving and processing images obtained by gamma camera ", PhD thesis, University of Belgrade – Faculty of Electrical Engineering, 2014 [In Serbian].

M. P. Sandler, R. E. Coleman, J. A. Patton, F. J. Th. Wackers and A. Gottschalk, Diagnostic Nuclear Medicine, 4th ed. Philadelphia: Lippincott Williams & Wilkins, 2003.

M. M. Janković, A. Koljević Marković and D. B. Popović, " Labview application for analysis of time activity curves in regions of small lesions in nuclear medicine ", In Proceedings of the 57th ETRAN Conference, 3-6 June, Zlatibor, 2013, pp. ME 1.9 1-5 [In Serbian].

J. S. Fleming and R. W. Kenny, "A comparison of techniques for the filtering of noise in the renogram, " Phys Med Biol, vol. 22, no. 2, pp. 359-364, Mar. 1977.

J. E. Jackson and J. Wiley, A user's guide to principal components. New York: John Wiley and Sons, Inc., 1991.

T. M. Lehmann, C. Gönner and K. Spitzer, "Interpolation Methods in Medical Image Processing, " IEEE Trans Med Imag, vol. 18, no. 11, pp. 1049-1075, Nov. 1999.

H. F. Kaiser, "An index of factorial simplicity," Psychometrika, vol. 39, pp. 31-36, 1974.

I. T. Jolliffe, Principal Component Analysis. 2nd ed. New York, USA: Springer, 2002.


  • There are currently no refbacks.

ISSN: 0353-3670 (Print)

ISSN: 2217-5997 (Online)

COBISS.SR-ID 12826626