Slobodan Davinić, Ivana Davinić, Ivan Tasić

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High rates of morbidity and mortality in patients with chronic diseases of the kidney are for the most part caused by the high prevalence of cardiovascular diseases and high rates of fatal cardiovascular events. The aim of the study was to establish the prevalence and distribution of cardiovascular risk factors in patients with chronic kidney diseases, in various stages of chronic renal failure. The examinees were classified into three groups based on the level of glomerular filtration rate: over 60 ml/min/1.73m2; 30-59 ml/min/1.73m2; and 15-29 ml/ min/1.73m2. Traditional risk factors of age, hypertension, systolic blood pressure, glycemia, diabetes, serum level of total cholesterol and triglycerides, triglyceridemia, and hypertrophy  of the left ventricle showed a significantly positive rising trend of their mean values or prevalence, inversely dependent upon the level of declining glomerular filtration rates. Mean values of serum HDL cholesterol level demonstrated a significant declining trend, concomitant with decreasing glomerular filtration rate. The prevalence of hypercholesterolemy, smoking and obesity, as well as the mean value of body mass index, showed significant intergroup variations, but without any continuing trend related to glomerular filtration rate. Non-traditional risk factors of anemia, proteinuria, and hypoalbuminemia showed a significant rising trend of prevalence inversely dependent upon the degree of reduction of glomerular filtration rate. The levels of hematocrit and serum albumins showed a positive correlation with the reduction of glomerular filtration rate. In pre-dialysis patients with chronic kidney diseases, a high prevalence of the studied cardiovascular risk factors was found. Cardiovascular risk progressively rises with decreasing glomerular filtration rate, being significantly elevated as early as the initial stages of renal failure.


chronic kidney disease, cardiovascular risk, cardiovascular morbidity

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Foley RN, Murray AM, Li S, Herzog CA, McBean AM, Eggers PW, Collins AJ. Chronic Kidney Disease and the Risk for Cardiovascular Disease, Renal Replacement, and Death in the United States Medicare Population, 1998 to 1999. J Am Soc Nephrol 2005; 16:489–495.

Weiner DE, Tabatabai S, Tighiouart H, Elsayed E, Bansai N, Griffith J, Salem DN, Levey AS, Sarnak MJ. Cardiovascular outcomes and all-cause mortality: exploring the interaction between chronic kidney disease and cardiovascular disease. Am J Kidney Dis 2006; 48(3):392–401.

Ruilope LM, Kjeldsen SE, de la Sierra A, Mancia G, Ruggenenti P, Stergiou GS, Bakris GL, Giles TD. The kidney and cardiovascular risk - implications for management: a consensus statement from the European Society of Hypertension. Blood Press 2007; 16(2): 72–79.

Levey AS, Coresh J. Chronic kidney disease. Lancet 2012; 14;379 (9811):165–180.

Foley RN, Wang C, Collins AJ. Cardiovascular Risk Factor Profiles and Kidney Function Stage in the US General Population: The NHANES III Study. Mayo Clin Proc 2005; 80:1270–1277.

Best PJM, Holmes Jr DR. Chronic kidney disease as a cardiovascular risk factor. Am Heart J March 2003; 145(3):383–386.

Weiner DE, Tighiouart H, Elsayed EF et al. The Framingham Predictive Instrument in Chronic Kidney Disease. J Am Coll Cardiol 2007; 50(3):217–224.

Gansevoort RT, Correa-Rotter R, Hemmelgarn BR et al. Chronic kidney disease and cardiovascular risk: epidemiology, mechanisms, and prevention. Lancet 2013; 382(9889):339–352.

Muntner P, He J, Astor BC, Folsom AR, Coresh J. Traditional and Nontraditional Risk Factors Predict Coronary Heart Disease in Chronic Kidney Disease: Results from the Atherosclerosis Risk in Communities Study. J Am Soc Nephrol 2005; 16:529–538.

Ruiz-Hurtado G, Sarafidis P, Fernández-Alfonso MS, Waeber B, Ruilope LM. Global cardiovascular protection in chronic kidney disease. Nat. Rev. Cardiol. 2016;13:603–608.

Sarnak MJ, Coronado BE, Greene T, Wang SR, Kusek JW, Beck GJ, Levey AS. Cardiovascular disease risk factors in chronic renal insufficiency. Clin Nephrol 2002; 57(5):327–335.

Jungers P, Massy ZA, Nguyen Khoa T, Fumeron C, Labrunie M, Lacour B, Descamps-Latscha B, Man NK. Incidence and risk factors of atherosclerotic cardiovascular accidents in predialysis chronic renal failure patients: a prospective study. Nephrol Dial Transplant 1997; 12:2597–2602.

Hallan SI, Orth SR. Smoking is a risk factor in the progression to kidney failure. Kidney Int 2011; 80:516–523.

Parikh NI, Hwang SJ, Larson MG, Meigs JB, Levy D, Fox CS. Cardiovascular Disease Risk Factors in Chronic Kidney Disease: Overall Burden and Rates of Treatment and Control. Arch Intern Med 2006; 166:1884–1891.

McDonald SP, Maguire GP, Hoy WE. Renal function and cardiovascular risk markers in a remote Australian Aboriginal community. Nephrol Dial Transplant 2003; 18:1555–1561.

Hoy WE, Mott SA, McDonald SP. An expanded nationwide view of chronic kidney disease in Aboriginal Australians. Nephrology 2016; 21(11):916–922.

Stenvinkel P, Zoccali C, Ikizler TA. Obesity in CKD—what should nephrologists know? J Am Soc Nephrol 2013; 24 (11):1727–1736.

Sun J, Axelsson J, Machowska A, et al. Biomarkers of Cardiovascular Disease and Mortality Risk in Patients with Advanced CKD. CJASN July 07, 2016 11): (7)1163–1172.



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