Milan Petrovic, Ljiljana Jeremic, Milan Radojkovic, Ivica Pejcic, Ivona Djordjevic, Milica Markovic, Jelena Stojanovic

DOI Number
First page
Last page


Sarcomas are soft tissue tumors arising from primitive mesenchyme. Small incidence (4-5/100 000 in Europe) is the reason their pathogenesis is relatively unknown. Patient (38) complained of a growth on the upper part of right thigh, the size of a child’s head. A magnetic resonance imaging (MRI) scan was done and tumefaction was described: oval shape, 13.5 x 7.5 x 11cm in diameter, without infiltration of surrounding tissue. The tumor was surgically removed and was pathohistologically verified as low grade liposarcoma myxoides. After initial presentation the patient presented a series of recurrences and metastases in the abdominal wall, extremities and  liver. Soft tissue metastasis from the lower extremities to the liver occur in 0.5% of cases and they are usually small and multiple, as in the presented patient. The European Sarcoma Medical Oncologist’s guide recommends that every  extremity tumor larger than 5cm and suspicious of malignancy should be evaluated using biopsy and imaging methods. A biopsy should be done before excision under ultrasound or computerized tomography (CT) guidance with the goal of planning the best therapy protocol and prevention of a generalized disease with metastases. The recommended imaging method is an MRI scan, although sarcomas can have a benign presentation.  Standard therapy includes surgical resection with local radiotherapy.  Liposarcoma myxoides, a rare soft tissue tumor, demands biopsy and complete surgical removal with detailed and continuous postoperative imaging follow-up and oncological therapy. The therapeutic goal is to increase survival and preserve extremity function.


Sarcoma, Liposarcoma

Full Text:



Stiller CA, Trama A, Serraino D, Rossi S, Navarro C, Chirlaque MD. Descriptive epidemiology of sarcomas in Europe: Report from the RARECARE project. Eur J Cancer 2013; 49(3):694-5.

Cormier JN, Pollock ER. Soft tissue sarcomas. CA Cancer J Clin 2004; 54:94-109.

Celik C, Karakousis CP, Moore R, Holyoke ED. Liposarcomas: Prognosis and Management. J Surg Oncol 1980; 14:245-9.

Fletcher CDM et al. WHO classification of tumours of soft tissue and bone. Lyon: IARC 2003:305-10.

Asano N, Susa M, Hosaka S, Nakayama R, Kobayashi E, Takeuchi K et al. Metastatic patterns of myxoid/round cell liposarcoma: a review of a 25-year experience. Sarcoma 2012.

Schwab JH, Boland P, Guo et al. Skeletal meastases in myxoid liposarcoma: an unusual pattern of distant spread. Ann Surg Oncol 2007; 14(4):150714.

Jaques D, Coit D, Casper E, Brennan M. Hepatic Metastases from Soft-Tissue Sarcoma. Ann Surg 1995; 4:392-7.

The ESMO / European Sarcoma Network Working Group. Soft tissue and visceral sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2014; 25(3):102-12.

Loubignac F, Bourtoul C, Chapel F. Myxoid liposarcoma: a rare soft-tissue tumor with a misleading benign appearance. World J Surg Oncol 2009; 7:42.

Trojani M, Contesso G, Coindre JM, et al. Soft-tissue sarcomas of adults: study of pathological prognostic variables and definition of a histopathological grading system. Int J Cancer 1984; 33:37-42.

Antman K, Crowley J, Balcerzak SP, et al. An intergroup phase III randomized study of doxorubicin and dacarbazine with or without ifosfamide and mesna in advanced soft tissue and bone sarcomas. J Clin Oncol 1993; 11:1276-85.

Kilpatric SE, Doyon J, Choong PFM Sim FH, Nascimento AG. The clinicopathologic spectrum of myxoid and round cell liposarcoma: a study of 95 cases. Cancer 1996; 77(8): 1450-8.

Orson GG, Sim FH, Reiman HM, Taylor WF. Liposarcoma of the musculoskeletal system. Cancer 1987; 60(6):1362-70.

Reitan JB, Kaalhus O, Brennhovd IO. Prognostic factors in liposarcoma. Cancer 1985; 55(10):2482-90.



  • There are currently no refbacks.

© University of Niš, Serbia
Creative Commons licence CC BY-NC-ND
ISSN 0354-4699 (Print)
ISSN 2406-050X (Online)