Vesna Kesić

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The number of young women treated for cancer who want to give birth is increasing, due to postponing pregnancy for older age. On the other hand, the disease is more often diagnosed in the early stage, when conservative treatment is much more successful, even in gynecological cancer. Most young women diagnosed with cancer can expect to live for decades after treatment, which makes many life issues, such as future fertility, increasingly important.  This has led to the separation of Oncofertility as a new field in oncology, which includes all procedures for the treatment of malignant disease with the aim of preserving fertility, but without compromising the oncological outcome. And while the problem of fertility may not be a priority at the time of diagnosis, over time it becomes more important. Infertility resulting from cancer treatment has a major impact on quality of life. The turmoil experienced by women who are simultaneously faced with cancer and possible loss of fertility leave emotional consequences, especially if the localization of the disease directly affects the reproductive organs. Coping not just with medical issues, but with two psychological traumas at the same time increases susceptibility to distress. Helping to preserve the quality of life and the psychological aspect of caring for patients with malignant diseases who want to preserve the possibility of childbirth should become an indispensable part of treatment. Recognizing and managing negative emotions in cancer patients is a priority that aims to improve their quality of life.


cancer, fertility, oncofertility, psychological distress

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Anderson C., H. B. Nichols. “Trends in Late Mortality Among Adolescent and Young Adult Cancer Survivors”. JNCI J Natl Cancer Inst 112, 10 (2020): 994–1002. doi:10.1093/jnci/djaa014

Benedict, C., J-A. Mc Leggon, B. Thom, J. F. Kelvin, M. Landwehr, S. Watson and

J. S. Ford. “Creating a family after battling cancer is exhausting and maddening”: Exploring real-world experiences of young adult cancer survivors seeking financial assistance for family-building after treatment”. Psychooncology 27, 12 (2018): 2829–2839. doi:10.1002/pon.4898.

Bray, F., J. Ferlay, I. Soerjomataram, R. L. Siegel, L. A. Torre, A. Jemal. “Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [published correction appears in CA Cancer J Clin 2020 Jul; 70 (4) :313]. CA Cancer J Clin 68, 6 (2018): 394–424. doi:10.3322/caac.21492

Canada, A. L., and L. R. Schover. “The Psychosocial Impact of Interrupted Childbearing in Longterm Female Cancer Survivors”. Psychooncology 21, 2 (2012): 134–143. doi: 10.1002/pon.1875

Carter, J., K. Rowland, D. Chi, C. Brown, N. Abu-Rustum, M. Castielb, and R. Barakat. “Gynecologic cancer treatment and the impact of cancer-related infertility”. Gynecol Oncology 97 (2005): 90–95. doi:10.1016/j.ygyno.2004.12.019

Carter, J., Y. Sonoda, and N. R. Abu-Rustum. “Reproductive concerns of women treated with radical trachelectomy for cervical cancer”. Gynecol Oncol 105, 1 (2007): 13–16. doi:10.1016/j.ygyno.2006.10.059

Carter, J., D. S. Chi, C. L. Brown, N. Abu-Rustum, M. Castiel, and R. Barakat. “Cancer-related infertility in survivorship”. International Journal of Gynecological Cancer 20, 1 (2010): 2–8. doi: 10.1016/j.ygyno.2004.12.019.

Carter, J., L. Raviv, L. Applegarth, J. S. Ford, L. Josephs, E. Grill, C. Sklar, Y. Sonoda, R. E. Baser, and R. R. Barakat. “A cross-sectional study of the psychosexual impact of cancer-related infertility in women: third-party reproductive assistance”. Journal of Cancer Survivorship 4, 3 (2010): 236–246. doi: 10.1007/s11764-010-0121-2

Chan, J. L. and E. T. Wang. “Oncofertility for women with gynecologic malignancies”. Gynecol Oncol 144, 3 (2017): 631–636. https://doi. org/10.1016/j.ygyno.2016.12.013

Corney, R., H. Everett, A. Howells, A. Howells, M. Crowther. “The care of patients undergoing surgery for gynaecological cancer: The need for information, emotional support and counselling”. J Adv Nurs 17 (1992): 667-671.

Deshpande, N. A., I. M. Braun, and F. L. Meyer. “Impact of fertility preservation counseling and treatment on psychological outcomes among women with cancer: A systematic review”. Cancer 121, 22 (2015): 3938–3947.

Duffy, C., and S. Allan. “Medical and Psychosocial Aspects of Fertility After Cancer”. Cancer J 15, 1 (2009): 27–33. doi: 10.1097/PPO.0b013e3181976602

Fleming, N. D., P. T. Ramirez, P. T. Soliman, K. M. Schmeler, G. B. Chisholm, A. M. Nick,

S. N. Westin and M. Frumovitz. “Quality of Life after Radical Trachelectomy for Early Stage Cervical Cancer: A 5-year Prospective”. Evaluation.Gynecol Oncol 143, 3 (2016): 596–603. DOI: 10.1016/j.ygyno.2016.10.012

Forman, E. J., C. K. Anders, and M. A. Behera. “A nationwide survey of oncologists regarding treatment-related infertility and fertility preservation in female cancer patients”. Fertility and Sterility 94, 5 (2010): 1652–1656.

Friedman, B. E., K. O’Leary, and L. M. Westphal. “Follow-up survey of cancer survivors who underwent ovarian stimulation for fertility preservation”. Fertility and Sterility 95, 4 (2011): supplement S12–S13.

Gamel, C., M. Hengeveld, and B. Davis. “Informational needs about the effects of gynaecological cancer on sexuality: A review of the literature”. J Clin Nurs 9 (2000): 5678.

Howlader, N., A. M. Noone, M. Krapcho, D. Miller, A. Brest, M. Yu, J. Ruhl, Z. Tatalovich, A. Mariotto, D. R. Lewis, H. S. Chen, E. J. Feuer, K. A. Cronin (eds). SEER Cancer Statistics Review, 1975–2017, National Cancer Institute. Bethesda, MD, 2020., based on November 2019 SEER data submission, posted to the SEER web site, April 2020.

Kesic V. “Psiho-socijalni i etički aspekti udruženosti kancera i trudnoće”. U Kancer, fertilitet i trudnoća, uredila V. Kesić, 332–347. Beograd: Zavod za izdavanje udžbenike, 2015.

La Rosa, V. L., M. Shah, I. Kahramanoglu, T. M. Cerentini, M. Ciebiera, L-T. Lin, M. Dirnfeld, P. Minona and J. Tesarik. “Quality of life and fertility preservation counseling for women with gynecological cancer: An integrated psychological and clinical perspective”. J Psychosom Obstet Gynaecol 1–7 (2019).

La Rosa, V., S. Garzon, G. Gullo, M. Fichera, G. Sisti, P. Gallo, G. Riemma, and A. Schiattarella. “Fertility preservation in women affected by gynaecological cancer: The importance of an integrated gynaecological and psychological approach”. Ecancer 14 (2020):1035.

Lee, S. J., L. R. Schover, A. H. Partridge, P. Patrizio, W. H. Wallace, K. Hagerty, L. N. Beck, L. V. Brennan and K. Oktay. “American Society Clinical Oncology recommendations on fertility preservation in cancer patients”. Journal of Clinical Oncology 24, 18 (2006): 2917–2931. doi: 10.1200/JCO.2006.06.5888.

Logan, S., J. Perz, J. M. Ussher, M. Peate, and A. Anazodo. “Systematic review of fertility‐related psychological distress in cancer patients: Informing on an improved model of care”. Psycho‐Oncology 28 (2019): 22–30. 10.1002/pon.4927

Loscalzo, M. J., K. L. Clark. “The Psychosocial Context of Cancer-Related Infertility”. In Oncofertility Fertility Preservation for Cancer Survivors edited by T. K. Woodruff, and K. A. Snyder. Cancer Treatment and Research 138 (2007): 180–190. Springer, Boston, MA. /

Matthews, M. L., B. S. Hurst, P. B. Marshburn, R. S. Usadi, M. A. Papadakis, and T. Sarantou. “Cancer, Fertility Preservation, and Future Pregnancy: A Comprehensive Review”. Obstetrics and Gynecology International Volume (2012): Article ID 953937. doi:10.1155/2012/953937

Nicholson, S. H. and J. Byrne. “Fertility and Pregnancy after Treatment for Cancer during Childhood and Adolescence”. Cancer 71 (1993): 3392–3399.<3392::AID-CNCR2820711743>3.0.CO;2-F

Oktay, K., B. E. Harvey, A. H. Partridge, G. P. Quinn, J. Reinecke, H. S. Taylor, W. H. Wallace, E. T. Wang, A. W. Loren. “Fertility Preservation in Patients With Cancer: ASCO Clinical Practice Guideline Update”. J Clin Oncol 36 (2018): 1994–2001. doi: 10.1200/JCO.2018.78.1914

Partridge, A. H., S. Gelber, J. Peppercorn, E. Sampson, K. Knudsen, M. Laufer, R. Rosenberg, M. Przypysny, A. Rein, and E. P. Winer. “Web-based survey of fertility issues in young women with breast cancer”. Journal of Clinical Oncology 22, 20 (2004): 4174–4183. doi: 10.1200/JCO.2004.01.159.

Raviv, L., L. Applegarth, J. S. Ford, L. Josephs, E. Grill, C. Sklar, Y. Sonoda, R. E. Baser, and R. R. Barakat. “A cross-sectional study of the psychosexual impact of cancer-related infertility in women: Third-party reproductive assistance”. Journal of Cancer Survivorship 4, 3 (2010): 236–246. doi: 10.1007/s11764-010-0121-2

Quinn, G. P., S. T. Vadaparampil, J-H. Lee, P. B. Jacobsen, G. Bepler, J. Lancaster, D. L. Keefe, and T. L. Albrecht. “Physician referral for fertility preservation in oncology patients: A national study of practice behaviors”. Journal of Clinical Oncology 27, 35 (2009): 5952–5957. doi: 10.1200/JCO.2009.23.0250

Quinn, G. P., D. Murphy, C. Knapp, D. K. Stearsman, K. L. Bradley-Klug, K. Sawczyn and M. L. Clayman. “Who decides? Decision making and Fertility Preservation in Teens with Cancer: A Review of the literature”. J Adolesc Health 49, 4 (2011): 337–346. doi:10.1016/j.jadohealth.2011.01.005

Robertson, J. A. “Cancer and Fertility: Ethical andLegal Chalenges”. J Natl Canc Inst Monog 34 (2005): 104–106. DOI: 10.1093/jncimonographs/lgi008

Rosen, A. “Third-party reproduction and adoption in cancer patients”. J Natl Cancer Inst Monogr 34 (2005): 91–93. doi: 10.1093/jncimonographs/lgi021

Rosenberg, K. “No Increased Risk of Genetic Damage in Children of Cancer Survivors”. American Journal of Nursing 112, 3 (2012): 16. doi: 10.1097/01.NAJ.0000412623.65014.6c

Sallem, A., J. Shore, I. Ray-Coquard, L. Ferreux, M. Bourdon, M. Maignien, C. Patrat, J-P. Wolf, and K. Pocate-Cheriet. “Fertility preservation in women with cancer: A national study about French oncologists awareness, experience, and feelings”. Journal of Assisted Reproduction and Genetics 35, 10 (2018): 1843–1850.

Signorello, L., J. L. Mulvihill, D. M. Green, H. M. Munro, M. Stovall, R. E. Weathers, A. C. Mertens, J. A. Whitton, L. L. Robison, and J. D. Jr Boice. “Congenital Anomalies in the Children of Cancer Survivors: A Report from the Childhood Cancer Survivor Study”. J Clin Oncol 30 (2012): 239–245. DOI: 10.1200/JCO.2011.37.2938

Nurden, S. K., B. I. Karp, M. R. Viera, S. Liu, A. Idriss, and P. Stratton. “Conveying future fertility risk to patients participating in clinical trials using total body irradiation or cytotoxic agents”. Fertility and Sterility 92 (2009) (supplement 3): S 184.

Young, K., K. Shliakhtsitsava, L. Natarajan, E. Myers, A. C. Dietz, J. R. Gorman, M. E. Martinez, B. W. Whitcomb, and H. I. Su. “Fertility counseling before cancer treatment and subsequent reproductive concerns among female adolescent and young adult cancer survivors”. Cancer 125, 6 (2019): 980–989. doi:10.1002/cncr.31862.



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