Maja Cvetković, Dušan Ilić, Maja Nikolić, Nenad Stošić, Marina Ranđelović

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The needs for micronutrients are increased during pregnancy primarily due to physiological changes and altered homeostatic control. Food, as the primary source of all nutrients, is not always sufficient to cover the increased needs, whereas the degree and frequency of nutritional deficiencies during pregnancy is various in demographic groups.

The aim of this paper was to investigate the nutritional intake of folic acid among pregnant women in Niš, Serbia.

The research was conducted in 2014 and 2015 which included pregnant women who lived on the territory of the City of Niš, between 20 and 35 years of age. The study was conducted by using the random sampling methodology, with 25 respondents included.

In our pilot study, a high percentage of pregnant women in the observed sample did not meet the guidelines for the daily intake of folic acid which also brought about an insufficient intake of other nutrients that are essential for pregnancy. The results of the conducted study undoubtedly point out to the need to implement supplementation schema improvement policy based on the individual nutritional status of every pregnant woman in order to reduce the possibilities of both insufficient and excessive intake of dietary supplements and the immediate risk to the health of the fetus.

There is an imperative need to strategically and generally inform the female population on the importance of the folic acid intake as well as the consequences that can appear due to insufficient intake.


folic acid, pregnant women, food, nutrition

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Institute of Medicine. Subcommittee on Nutritional Status and Weight Gain during, Pregnancy. Nutrition during pregnancy. Part I: weight gain. Part II: nutrient supplements.Washington, DC: National Academy of Sciences; 1990.

Picciano MF. Pregnancy and lactation: physiological adjustments, nutritional requirements and the role of dietary supplements. J Nutr. 2003;133:S1997–2002.

Turner RE, Langkamp-Henken B, Littell RC, Lukowski MJ, Suarez MF.Comparing nutrient intake from food to the estimated average re-quirements shows middle- to upper-income pregnant women lack iron and possibly magnesium. J Am Diet Assoc.2003;103:461- 6.

Kaiser L, Allen LH, American Dietetic Association. Position of the American Dietetic Association: nutrition and lifestyle for a healthy pregnancy outcome. J Am Diet Assoc. 2008;108:553–61.

Hoellen F, Hornemann A, Haertel C, Reh A, Rody A, Schneider S, Tuschy B, Bohlmann MK. Does maternal underweight prior to conception influence pregnancy risks and outcome? In Vivo. 2014; 28(6):1165-70.

Musa MG, Torrens C, Clough GF.The microvasculature: a target for nutritional programming and later risk of cardio-metabolic disease.Acta Physiol (Oxf). 2014 ;210(1):31-45.

Kocic G., Bjelakovic G., Djordjevic V., Nikolic J., Pavlovic D., Koraćević D., Biohemija, Savremena administracija, Beograd 2006

Banjari I, Matoković V, Škoro V. The question is whether intake of folic acid from diet alone during pregnancy is sufficient. Med pregl 2014; 67( 9-10): 313-321.

Schlotz W1, Jones A, Phillips DI, Gale CR, Robinson SM, Godfrey KM. Lower maternal folate status in early pregnancy is associated with childhood hyperactivity and peer problems in offspring. J Child Psychol Psychiatry. 2010;51(5):594-602.

Wilson RD; Genetics Committee, Wilson RD, Audibert F, Brock JA, Carroll J, Cartier L. et al. Pre-conception Folic Acid and Multivitamin Supplementation for the Primary and Secondary Prevention of Neural Tube Defects and Other Folic Acid-Sensitive Congenital Anomalies. J Obstet Gynaecol Can. 2015 ;37(6):534-52.

Chitayat D, Matsui D, Amitai Y, Kennedy D, Vohra S, Rieder M, Koren G. Folic acid supplementation for pregnant women and those planning pregnancy: 2015 update. J Clin Pharmacol. 2015 Aug 13. doi: 10.1002/jcph.616.

Nikolić M. Ur. Dijetetika, Medicinski fakultet u Nišu, Niš. 2008.

Jokić N, Dimić M, Pavlica M. Tablice hemijskog sastava prehrambenih proizvoda, Zavod za ekonomiku stanovništva Srbije, Beograd,1999.

Brodarec A. Tablice o sastavu i prehrambenoj vrijednosti namirnica i pića, Zavod za zaštitu zdravlja Hrvatske, Zagreb 1976.

Bestwick JP, Huttly WJ, Morris JK, Wald NJ. Prevention of neural tube defects: a cross-sectional study of the uptake of folic acid supplementation in nearly half a million women. PloS one 2014; 9(2):e89354.

Amitai Y, Koren G. The Folic Acid Rescue Strategy: High-Dose Folic Acid Supplementation in Early Pregnancy.JAMA Pediatr. 2015 5:1-2.

Gomes S1, Lopes C1, Pinto E2. Folate and folic acid in the periconceptional period: recommendations from official health organizations in thirty-six countries worldwide and WHO. Public Health Nutr. 2015 16:1-14. [Epub ahead of print]

Ivanović N, Đorđević B. Opravdanost upotrebe dodataka ishrane u populaciji trudnica.Arhiv za farmaciju 2014; 64( 5):438-451.

Gujska G. Majewska K. (2005): Effect of Baking Process on Added Folic Acid and Endogenous Folates Stability in Wheat and Rye Breads, Plant Foods for Human Nutrition, 60, str. 37-42.

Klein BP, Kuo CHY, Boyd G. Folacin and ascorbic acid retention fresh raw, microwave, and conventionally cooked spinach, Journal of Food Science (1981); 46: 640-641


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