THE APPLICATION OF BISPHOSPHONATES IN THE TREATMENT OF PATIENTS WITH DISTURBED RENAL FUNCTION - CASE REPORT

Abstract

Renal osteodystrophy and osteoporosis are related to chronic renal disease. In the present research and clinical dilemmas, indications have been proposed concerning the possible application of bisphosphonates in patients suffering from renal insufficiency. The aim of the study is to present a patient with disturbed renal function who was treated with parenteral bisphosphonates. The patient is a 56-year old male who was receiving hemodialysis for 29 years. In order to estimate risk for further bone fractures and to evaluate possible indication for intravenous bisphosphonates a bone mineral densitometry was performed, as well as transiliac biopsy with histological examination of the bone. The etiology of bone fractures in renal patients is multifactorial and cannot be fully explained only with the aid of pathohistological examination. After the thorough diagnostics, it could be possible to apply bisphosphonates in the treatment of patients with renal osteodystrophy on chronic hemodialysis or peritoneal dialysis.