FERROCENE-CONTAINING CHOLINESTERASE INHIBITORS

Marija S. Genčić, Jelena D. Živanović, Jelena M. Denić, Danijela N. Nikolić, Niko S. Radulović

DOI Number
https://doi.org/10.2298/FUPCT2401037G
First page
037
Last page
051

Abstract


Inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) represents the most established treatment strategy for Alzheimer's disease, which is marked by a deficiency of acetylcholine in the brain. The inhibitory effects of ferrocene derivatives on cholinesterases have not been as thoroughly investigated as their antimalarial and antiproliferative properties. This short review details the advancements in this area since 1962 when the first ferrocene derivative was assessed for its effects. To date, approximately 100 structurally diverse ferrocene-containing compounds have been evaluated for their inhibitory activity against AChE and/or BChE, with several demonstrating promising effects in the low micromolar or submicromolar range. The most active derivatives have emerged from the bioisosteric replacement of the aryl group with a ferrocene unit in known inhibitors or through the development of hybrids that link ferrocene with established inhibitors. It is encouraging to note that research in this field has intensified over the past five years, promising substantial progress soon.

Keywords

ferrocene, acetylcholinesterase, butyrylcholinesterase, inhibitor, Alzheimer’s disease, Parkinson’s disease

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References


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