MODELLING AND SIMULATION OF NONLINEAR DYNAMIC FLOW FIELD AND TEMPERATURE FIELD OF DEPYROGENATION TUNNEL

Yizhi Wang, Quanmin Zhu, Tao Huang, Xiaodong Han, Min Lin

DOI Number
https://doi.org/10.22190/FUME221221011W
First page
045
Last page
062

Abstract


Nonlinear dynamics plays a crucial role particularly in equipment validation of preparation production, validation results of which will significantly influence the results and period of drug registration in drug production processes. In this research, the flow field and temperature field simulation, calculation and analysis are creatively carried out in terms of depyrogenation tunnel, a very popular preparation drying-sterilization equipment in pharmaceutical processes with strong dynamic characteristics. After construction of 3D model of this equipment using Catia and mesh generation applying ANSYS, the computational fluid dynamic (CFD) method and verification of irrelevance method are carried out regarding 6.05 million of meshes to identify the flow velocity model and heat transfer model inside the equipment, to further provide methodology for pharmaceutical process validation and to further optimize the design of control methods. After calculation and simulation, the low-velocity vortices of different sizes inside the hood and the drying chamber are identified, which could cause vials to fall down; meanwhile, vials that are farther away from the outlet receives less heat exchange effect, which would shrink the effective sterilization area, indicating an inadequate validation methodology in pharmaceutical processes.

Keywords

Depyrogenation Tunnel, Flow Field, Temperature Field, Nonlinear Dynamic Simulation

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References


Huang, L., Zhou, Y., Wang, Y., Lin, M., 2021, Optimization of S-Nitrosocaptopril Monohydrate Storage Conditions Based on Response Surface Method, Molecules, 26(24), 7533

Krüger, O., Ebner, I., Kappenstein, O., Roloff, A., Luch, A., Bruhn, T., 2021, Towards a better comparability during GMP assessment–Identifying the main parameters that influence the loss of volatile organic compounds from silicone elastomers, Food Packaging and Shelf Life, 30, 100758

Wang, Y., Yang, Z., Gu, S., Chen, W., Yu, Z., 2021, Research on pole placement approach of non-standard state space model with case study, International Journal of Modelling, Identification and Control, 37(3-4), pp. 249-257.

Wang, Y., Zhu, Q., Nibouche, M., 2015, State-space Modelling and Control of a MIMO Depyrogenation Tunnel, 34th Chinese Control Conference, pp. 674-679.

Wang, Y., Zhu, Q., Nibouche, M., 2015, Mamdani type controller design for MIMO systems with case study, 2015 7th International Conference on Modelling, Identification and Control (ICMIC), IEEE, pp. 1-6

Komissarov, A.V., Bibikov, D.N., Badarin, S.A., Sinitsyna, N.V., Kostyleva, N.I., Ovchinnikova, M.V., Korovkina, G.I., Zinina, O.S., Plotnikov, I.A., Nikiforov, A.K., 2020, Calculation of dependences for estimating the amount of weight loss during lyophilization of diagnostic preparations, Proceedings of Universities, Applied Chemistry and Biotechnology, 10(3), pp. 506-514.

Boom, F., Le, B., Paul, P., Boehringer, S., Kosterink, J., Touw, D., 2021, Improving the aseptic transfer procedures in hospital pharmacies part A: methods for the determination of the surface bioburden on ampoules and vials, European journal of hospital pharmacy, Science and practice, 28 (1), pp. 38–41.

Gupta, S., Román-Ospino, A.D., Baranwal, Y., Hausner, D., Ramachandran, R., Muzzio, F.J., 2021, Performance assessment of linear iterative optimization technology (IOT) for Raman chemical mapping of pharmaceutical tablets, Journal of Pharmaceutical and Biomedical Analysis, 205, 114305

Hussain, S.M., Jamshed, W., 2021, A comparative entropy based analysis of tangent hyperbolic hybrid nanofluid flow: Implementing finite difference method, International Communications in Heat and Mass Transfer, 129, 105671

Yu, Z., Song, Y., Song, D., Liu, Y., 2021, Spatial interpolation-based analysis method targeting visualization of the indoor thermal environment, Building and Environment, 188, 107484

Gumbarević, S., Milovanović, B., Gaai, M., Bagarić, M., 2021, Thermal transmittance prediction based on the application of artificial neural networks on heat flux method results, Journal of Physics: Conference Series, 2069, 012152

Bel-Rhlid, R., Berger, R.G., Blank, I., 2018, Bio-mediated generation of food flavors–Towards sustainable flavor production inspired by nature, Trends in Food Science & Technology, 78, pp. 134-143.

Paton, J., Khatir, Z., Thompson, H., Kapur, N., Toropov, V., 2013, Thermal energy management in the bread baking industry using a system modelling approach, Applied Thermal Engineering, 53(2), pp. 340-347.

Khatir, Z., Paton, J., Thompson, H., Kapur, N., Toropov, V., 2013, Optimisation of the energy efficiency of bread-baking ovens using a combined experimental and computational approach, Applied energy, 112, pp. 918-927.

Khatir, Z., Taherkhani, A.R., Paton, J., Thompson, H., Kapur, N., Toropov, V., 2015, Energy thermal management in commercial bread-baking using a multi-objective optimisation framework, Applied Thermal Engineering, 80, pp. 141-149.

Tanthadiloke, S., Chankerd, W., Suwatthikul, A., Lipikanjanakul, P., Mujtaba, I.M., Kittisupakorn, P., 2016, 3D computational fluid dynamics study of a drying process in a can making industry, Applied Thermal Engineering, 109, pp. 87-98.

Dhayal, P., Chhanwal, N., Anandharamakrishnan, C., 2013, Heat transfer analysis of sterilization of canned milk using computational fluid dynamics simulations, Journal of Food Science and Engineering, 3(11), 571

Ji, Z., 2019, Discussion on improvement of hot air circulation oven, Chemical Enterprise Management, 11, pp. 141–142.

Yu, M., Geng, Y., 2017, Study on uniformity of air supply in air duct of sleeper vehicle, Railway technical supervision, China, 45(1), pp. 41–43.

Wan, M., 2012, Design and study of laminar hot air sterilization tunnel oven, Master thesis, Shaanxi University of Science and Technology.

Wan, M.W., Zhang, S.H., 2012, Numerical Simulation of the Tunnel Oven with Fluent Software, Advanced Materials Research, 399, pp. 1856-1861.

Wang, B., Yu, Y., Lu, C., 2014, Simulation of temperature rise curve of Celine bottle based on FLUENT, Chemical and Pharmaceutical Engineering, 35(3), pp. 43-47.

Dimou, A., Yanniotis, S., 2011, 3D numerical simulation of asparagus sterilization in a still can using computational fluid dynamics, Journal of Food Engineering, 104(3), pp. 394-403.

ANSYS, Inc, ANSYS FLUENT Theory Guide, 2012, 10 version 14.5, pp. 47-49.

Wang, Z., Zou, Y., Liu, B., Zhang, Z., 2020, Flow Field Simulation and Structure Optimization of Hot Air Circulation Tunnel Oven, Chinese Journal of Process Engineering, 20(5), pp. 531-539.




DOI: https://doi.org/10.22190/FUME221221011W

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ISSN: 0354-2025 (Print)

ISSN: 2335-0164 (Online)

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