ANTIOXIDANTS AND THEIR IMPORTANCE DURING MUSCULAR EXERCISE: A REVIEW

Ljiljana Bjelaković, Gordana Kocic, Dragan Radovanovic, Vladimir Antic, Bojko Bjelakovic, Zorica Antic

DOI Number
10.22190/FUMB160918002B
First page
48
Last page
56

Abstract


Physiological levels of reactive oxygen species, as an essential part of the homeostatic milieu, are required for normal functioning of skeletal muscle. High levels of reactive oxygen species promote contractile dysfunction resulting in muscle weakness and fatigue, oxidative stress, apoptosis and necrosis of muscle cells. It is known that both resting and contracting skeletal muscles produce reactive oxygen species and reactive nitrogen species. The first suggestion that physical exercise results in free radical-mediated damage to tissues appeared in 1978. The newest researches investigate the mechanisms by which oxidants influence skeletal muscle contractile properties and explore how to protect muscle from oxidant-mediated dysfunction. Principal antioxidant enzymes include superoxide dismutase, glutathione peroxidase, and catalase. Numerous non-enzymatic antioxidants exist in cells within skeletal muscle fibers, the most abundant of which include glutathione, bilirubin, α-Lipoic acid , uric acid, and ubiquinones, or coenzyme Q (CoQ) andflavonoids. Dietary antioxidants are vitamins C- L ascorbic acid , vitamin A, retinol and their provitamins, carotenoids (especially β-carotene), vitamins E, tocopherol (especially a-tocoferol ), folic acid or folates. The usage of endogenous enzymatic and non-enzymatic antioxidants protects muscle from strong damaging effects caused by free radicals during acute exercise or longer term physical exercise. Scientific researches now confirm that the long-term use of antioxidants is safe and effective. The actual recommendation for physically active individuals is to ingest a diet rich in antioxidants.


Keywords

physical activity, human body, antioxidants, diet

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References


Lehninger AL, Nelson DL, Cox MM. Oxidative phophorylation and photophosphorylation. In: Nelson DL, Cox MM (ed) Principles of biochemistry, 4th Ed., WH Freeman Co: New York, 2004; pp. 542–596

Powers SK, Ji LL, Kavazis AN, Jackson MJ. Reactive oxygen species: impact on skeletal muscle. Compr Physiol 2011; 1(2): 941–969.

Kanter M. Free radicals, exercise and antioxidant supplementation. mechanisms and impact on muscle force production. Proc Nutr Soc 1998; 57(1):9–13.

Smith MA, Reid MB. Redox modulation of contractile function in respiratory and limb skeletal muscle. Respir Physiol Neurobiol 2006; 151(2–3):229–241.

Radak Z, Zhao Z, Koltai E, Ohno H, Atalay M. Oxygen consumption dependent adaptive signaling. Antioxid Redox Signal 2013; 18(10):1208–1246.

McArdle A, Jackson MJ. Exercise, oxidative stress and ageing. Anat 2000; 197(Pt 4):539–541.

Pattwell DM, McArdle A, Morgan JE, Patridge TA, Jackson MJ. Release of reactive oxygen and nitrogen species from contracting skeletal muscle cells. Free Radic Biol Med 2004; 37:1064–1072.

Gomez-Cabrera MC, Ferrando B, Brioche T, Sanchis-Gomar F, Vina J. Exercise and antioxidant supplements in the elderly. J Sport Health Sci 2013; (2):94–100.

Davies KJ, Quintanilha AT, Brooks GA, Packer L. Free radicals and tissue damage produced by exercise. Biochem Biophys Res Commun 1982; 107:1198–1205.

Sjödin B, Hellsten Westing Y, Apple FS. Biochemical mechanisms for oxygen free radical formation during exercise. Sports Med 1990; 10(4):236–254.

Harris RA, Crabb DW. Metabolic interrelationships. In: Devlin TM (ed) Textbook of biochemistry with clinical correlations, fourth edition. A John Wiley & Sons. Inc., Publication: New York, 1997: 525562.

Hallwell B. The antioxidant paradox: less paradoxiocal now? Br J Clin Pharmacol 2013; 75(3):637–644.

Powers SK, Jackson MJ. Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production. Physiol Rev 2008; 88:1243–1276

Powers SK, Lennon SL. Analysis of cellular responses to free radicals: focus on exercise and skeletal muscle. Proc Nutr Soc 1999; 58(4):1025–1033.

Jackson MJ, Pye D, Palomero J. The production of reactive oxygen and nitrogen species by skeletal muscle. J Appl Physiol 2007; 102(4):1664–1670.

Ji LL. Antioxidants and oxidative stress in exercise. Proc Soc Exp Biol Med 1999; 222(3):283–292.

Horton JW. Free radicals and lipid peroxidation mediated injury in burn trauma: the role of antioxidant therapy. Toxicology 2003; 189:75–88.

Bjørneboe A, Bjørneboe GE, Drevon CA. Absorption, transport and distribution of vitamin E. J Nutr 1990; 120(3):233–242.

Urso ML, Clarkson PM. Oxidative stress, exercise, antioxidant supplementation. Toxicology 2003; 189:41–54.

Powers SK, Talbert EE, Adhihetty PJ. Reactive oxygen and nitrogen species as intracellular signals in skeletal muscle. J Physiol 2011; 589(Pt 9):2129–2138.

Cortez-Toledo O, Schnair C, Sangngern P, Metzger D, Chao LC. Nur77 deletion impairs muscle growth during developmental myogenesis and muscle regeneration in mice. Berdeaux R, editor. PLoS One [Internet]. 2017 Feb 7 [cited 2017 Feb 12];12(2):e0171268

Higuchi M, Cartier LJ, Chen M, Holloszy JO, Kanter MM. Superoxide dismutase and catalase in skeletal muscle: adaptive response to exercise. J Gerontol 1985; 40(3):281–286.

Ji LL. Exercise and oxidative stress: role of the cellular antioxidant systems. Exerc Sport Sci Rev 1995; 23:135–166.

Vina J, Gomez-Cabrera M-C, Lloret A, Marquez R, Minana JB, Pallardo FV, Sastre J. Free radicals in exhaustive physical exercise: mechanism of production, and protection by antioxidants. IUBMB Life 2000; 50:271–277.

Jacob RA. Trace elements. In: Tietz NW (ed) Textbook of clinical chemistry. W.B. Saunders: Philadelphia; 1986: 965–996.

Borges L da S, Dermargos A, Junior EP da S, Weimann E, Lambertucci RH, Hatanaka E. Melatonin decreases muscular oxidative stress and inflammation induced by strenuous exercise and stimulates growth factor synthesis. J Pineal Res [Internet]. 2015 Mar [cited 2017 Feb 12];58(2):166–72.

Culotta VC, Yang M, O'Halloran TV. Activation of superoxide dismutases: Putting the metal to the pedal. Biochim Biophys Acta 2006; 1763(7):747–758.

Abreu IA, Cabelli DE. Superoxide dismutases-a review of the metal-associated mechanistic variations. Biochim Biophys Acta 2010; 1804(2):263–274.

Powers SK, Ji LL, Leeuwenburgh C. Exercise training-induced alterations in skeletal muscle antioxidant capacity: a brief review. Med Sci Sports and Exerc 1999; 31(7):987–997.

Hassan HM, Fridovich I. Chemistry and biochemistry of superoxide dismutases. Eur J Rheumatol Inflamm 1981; 4(2):160–172.

Arora S, Button DC, Basset FA, Behm DG. The effect of double versus single oscillating exercise devices on trunk and limb muscle activation. Int J Sports Phys Ther 2013; 8(4):370–380.

Chance B, Sies H, Boveris A. Hydroperoxide metabolism in mammalian organs. Physiol Rev 1979; 59(3):527–605.

Moss DW, Henderson AR, Kachmar JF. Enzymes. In: Tietz NW (ed). The textbook of Clinical Chemistry. W. B. Saunders Company: Philadelphia, 1986:619–774.

Arnér ES, Holmgren A. Physiological functions of thioredoxin and thioredoxin reductase. Eur J Biochem. 2000; 267(20):6102– 6109.

Norberg J, Arner ES. Reactive oxygen species, antioxidants, and the mammalian thioredoxin system. Free Radic Biol Med 2001; 31(11):1287–1312.

Rhee SG, Woo HA, Kil IS, Bae SH. Peroxides and a regulator and sensor of local peroxiredoxin functions as a peroxidase. J Biol Chem 2012; 287:4403–4410.

Holmgren A. Antioxidant function of thioredoxin and glutaredoxin systems. Antioxid Redox Signal 2000; 2(4):811–820.

McCormick DK. Vitamins. Chapter 8B. In Tietz NW (ed), The textbook of Clinical Chemistry. W. B. Saunders Company: Philadelphia, 1986:927–964.

Fujii J, Ikeda Y. Advances in our understanding of peroxiredoxin, a multifunctional, mammalian redox protein. Redox Report 2002; 7(3):1–8.

Englard S, Seifter S. The Biochemical Functions of Ascorbic Acid. Annu Rev Nutr [Internet]. 1986 Jul [cited 2017 Feb 12];6(1):365–406.

Sirmali R, Ginis Z, Sirmali M, Solac O, Şeliman B, Agackiran Y, Delibas N. Vitamin C as an antioxidant: evaluation of its role on pulmonary contusion experimental model. Turk J Med Sci 2014; 44:905–913.

Tsuchihashi H, Kigoshi M, Iwatsuki M, Niki E. Action of β-Carotene as an Antioxidant against Lipid Peroxidation. Archiv Biochem Biophys 1995; 323(1):137–147.

Traber MG. Relationship of vitamin E metabolism and oxidation in exercising human subjects. Br J Nutrition 2006; 96 (Suppl. 1):S34–S37.

Linus Pouling Institute, Oregon State University. Micronutrient Information Center. Lipoic acid; Chlorophyll and orophyllin. Copyright 2016.

Tan ML, Foong SC, Foong WC, Yusuff Y, Chettiar SM. Tocotrienol-rich fractions (TRF) supplementation in school-going children with Attention Deficit/Hyperactive Disorder (ADHD): a randomized controlled trial. BMC Nutrition 2016; 2(14):1–9.

Taridi NM, Yahaya MF, Teoh SL, Latiff AA, Ngah WZ, Das S, Mazlan. Tocotrienol rich fraction (TRF) supplementation protects against oxidative DNA damage and improves cognitive functions in Wistar rats. Clin Ter 2011; 162(2):93–98.

Warren JA, Jenkins RR, Packer L, Witt EH, Armstrong RB. Elevated muscle vitamin E does not attenuate eccentric exercise-induced muscle injury. J Appl Physiol (1985) 1992; 72(6):2168– 2175.

Stepanyan V, Crowe M, Haleagrahara N, Bowden B. Effects of vitamin E supplementation on exercise-induced oxidative stress: a meta-analysis. Appl Physiol Nutr Metab 2014; 39(9):1029–1037.

Clarkson PM, Thompson HS. Antioxidants: what role do they play in physical activity and health? Am J Clin Nutr 2000; 72(suppl):637S–646S.

Linus Pauling Institute, Oregon State University. Micronutrient Information Center. Folate. Copyright 2016.

Bailey LB, Gregory JF. Folate metabolism and requirements. J Nut 1999; 129:779–782.

King MW, PhD | © 1996–2016 themedicalbiochemistrypage. (2016): Vitamins and Minerals. org, LLC | info @ themedicalbiochemistrypage. org, Last updated August 11, 2016.

Jackson MJ. Reactive oxygen species and redox-regulation of skeletal muscle adaptations to exercise. Phil Trans R Soc B 2005; 360; 2285–2291.

Anstee QM, Day CP. S-adenosylmethionine (SAMe) therapy in liver disease: a review of current evidence and clinical utility. J Hepatol 2012; 57(5):1097–1099.

Fang Y-Z, Yang SH, Wu G. Free Radicals, antioxidants, and nutrition. Nutrition 2002; 18 (10):872–879.

Prudova A, Bauman Z, Braun A, Vitvitsky V, LuS C, Banerjee R. Sadenosylmethionine stabilizes cystathionine beta-synthase and modulates redox capacity. Proc Natl Acad Sci U S A 2006; 103 (17):6489–6494.

Wang SC, Frey PA. S-adenosylmethionine as an oxidant: the radical SAM superfamily. Trends Biochem Sci 2007; 32(3): 101–110.

Wu G, Fang Y-Z, Yang S, Lupton JR, Turner ND. Glutathione metabolism and its implications for health. J Nutr 2004; 134(3): 489–492.

Radak Z, Chung HY, Goto S. Systemic adaptation to oxidative challenge induced by regular exercise. Free Radic Biol Med 2008; 44:153–159.

Reid MB. Invited Review: Redox modulation of skeletal muscle contraction: what we know and what we don't. J Appl Physiol (1985) 2001; 90(2):724–731.

Reid MB, Durham WJ. Generation of reactive oxygen and nitrogen species in contracting skeletal muscle: potential impact on aging. Ann N Y Acad Sci 2002; 959:108–116.

Leeuwenburgh C, Fiebig R, Chandwaney R, Ji LL. Aging and exercise training in skeletal muscle: responses of glutathione and antioxidant enzyme systems. Am J Physiol 1994; 267: R439–R445.

Chen G, Chen Z, Hu Y, Huang P. Inhibition of Mitochondrial Respiration and Rapid Depletion of Mitochondrial Glutathione by β-Phenethyl Isothiocyanate: Mechanisms for Anti-Leukemia Activity. Antioxid Redox Signal [Internet]. 2011 Dec 15 [cited 2017 Feb 12];15(12):2911–21.

Sedlak TW, Saleh M, Higginson DS, Paul BD, Juluri KR, Snyder SH. Bilirubin and glutathione have complementary antioxidant and cytoprotective roles. Proc Natl Acad Sci U S A. 2009; 106(13):5171–5176.

Swift D, Johannsen NM, Earnest CP, Blair SN, Church TS. The effect of different doses of aerobic exercise training on total bilirubin levels. Med Sci Sports Exerc 2012; 44(4):569–574.

Abraham NG, Kappas A. Pharmacological and Clinical Aspects of Heme Oxygenase. Pharmacol Rev [Internet]. 2008 Mar 6 [cited 2017 Feb 12];60(1):79–127.

Jansen T, Daiber A. Direct antioxidant properties of bilirubin and biliverdin. Is there a role for biliverdin reductase? Front Pharmacol 2012; 3:30.

Ziberna L, Martelanc M, Franko M, Passamonti S. Bilirubin is an endogenous antioxidant in human vascular endothelial cells. Sci Rep 2016;6: 29240. DOI: 10. 1038/srep29240

Barañano D, Rao M, Ferris CD, Snyder SH. Biliverdin reductase: major physiologic cytoprotectant. Proc Natl Acad Sci U S A 2002; 99(25):16093–16098.

Stocker R, Glazer AN, Ames BN. Antioxidant activity of albumin-bound bilirubin. Proc Natl Acad Sci USA 1987; 84:5918–5922.

Smith AR, Shenvi SV, Widlansky M, Suh JH, Hagen TM. Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress. Curr Med Chem 2004; 11(9):1135–1146.

Tort F, Ferrer-Cortes X, Ribes A Differential diagnosis of lipoic acid synthesis defects J Inherit Metab Dis. 2016; 39(6):781-793. Epub 2016 Sep 1.

Packer L, Witt EH, Tritschler HJ. Alpha-Lipoic acid as a biological antioxidant. Free Radic Biol Med 1995; 19(2):227–250.

Moini H, Packer L, Saris NE. Antioxidant and prooxidant activities of alpha-lipoic acid and dihydrolipoic acid. Toxicol Appl Pharmacol 2002; 182(1):84–90.

Zembron-Lacny A, Slowinska-Lisowska M, Szygula Z, Witkowski K, Stefaniak T, Dziubek W. Assessment of the antioxidant effectiveness of alpha-lipoic acid in healthy men exposed to muscle-damaging exercise. J Physiol Pharmacol 2009; 60(2): 139–143.

Petersen SK, Moreau RF, Smith EJ, Hagen TM. Is alpha-lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity. IUBMB Life 2008; 60(6):362–367.

Kagan VE, Shvedova A, Serbinova E, Khan S, Swanson C, Powell R, Packer L. Dihydrolipoic acid--a universal antioxidant both in the membrane and in the aqueous phase. Reduction of peroxyl, ascorbyl and chromanoxyl radicals. Biochem Pharmacol 1992; 44(8):1637–1649.

Sautin YY, Johnson RJ. Uric acid: the oxidant-antioxidant paradox. Nucleosides Nucleotides Nucleic Acids 2008; 27(6):608–619 .

deOliveira EP, Burini RC. High plasma uric acid concentration: causes and consequences. Diabetol Metab Syndr 2012; 4(12):1–7.

Waring WS, Convery A, Mishra V, Shenkin A, Webb DJ, Maxwell SR: Uric acid reduces exercise-induced oxidative stress in healthy adults. Clin Sci (Lond) 2003; 105(4):425–430.

Malaguti M, Angeloni C, Hrelia S. Polyphenols in exercise performance and prevention of exercise-induced muscle damage. Oxid Med Cell Longev 2013; 2013:825928. doi: 10.1155/2013/825928.

Ernster L, Dallner G. Biochemical, physiological and medical aspects of ubiquinone function. Biochim Biophys Acta 1995; 1271(1):195–204.

Crane FL. Biochemical functions of coenzyme Q10. J Am Coll Nutr 2001; 20(6):591–598.

Molyneux S L, Young JM, Florkowski CM, Lever M, George PM. Coenzyme Q10: Is there a clinical role and a case for measurement? Clin Biochem Rev Vol 2008; 29:71–82.

Laaksonen R, Fogelholm M, Himberg JJ, Laakso J, Salorinne Y. Ubiquinone supplementation and exercise capacity in trained young and older men. Eur J Appl Physiol Occup Physiol 1995; 72(1–2):95–100

Littarru GP, Tiano LBioenergetic and antioxidant properties of coenzyme Q10: recent developments. Mol Biotechnol 2007; 37(1):31–37.

Zuliani U, Bonetti A, Campana M, Cerioli G, Solito F, Novarini A. The influence of ubiquinone (Co Q10) on the metabolic response to work. J Sports Med Phys Fitness 1989; 29(1):57–62.

Cooke M, Iosia M, Buford T, Shelmadine B, Hudson G, Kerksick C, et al. Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals. J Int Soc Sports Nutr 2008; 4;5:8. doi: 10.1186/1550-2783-5-8.

Kon M, Kimura F, Akimoto T, Tanabe K, Murase Y, Ikemune S, Kono I. Effect of Coenzyme Q10 supplementation on exercise-induced muscular injury of rats. Exerc Immunol Rev 2007; 13:76–88.

Svensson M, Malm C, Tonkonogi M, Ekblom B, Sjodin B, Sahlin K. Effect of Q10 supplementation on tissue Q10 levels and adenine nucleotide catabolism during high-intensity exercise. Int J Sport Nutr 1999; 9(2):166–180.

Middleton E, Kandaswami C, Theoharid TC. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 2000; 52 (4):673–751.

Pal D, Verma P. Flavonoids: a powerful and abundant source of antioxidants. Int J Pharm Pharm Sci 2013; 5(3):95–98.

Pietta PG. Flavonoids as antioxidants. J Nat Prod 2000; 63(7):1035–1042.

Terao J. Dietary flavonoids as antioxidants. Forum Nutr 2009; 61:87–94.

Nieman DC, Williams AS, Shanely RA, Jin F, McAnulty SR, Triplett NT, Austin MD, Henson DA. Quercetin's influence on exercise performance and muscle mitochondrial biogenesis. Med Sci Sports Exerc 2010; 42(2):338–45.

Ferruzzi MG. Antioxidant and antimutagenic activity of dietary chlorophyll derivatives determined by radical scavenging and bacterial reverse mutagenesis assays. Food Sci 2006; 67(7):2589–2595.

Hsu CY, Chao PY, Hu SP, Yang CM. The antioxidant and free radical scavenging activities of chlorophylls and pheophytins. Food Nutr Sci, 2013; 4:1–8.

Kamat JP, Boloor KK, Devasagayam TP. Chlorophyllin as an effective antioxidant against membrane damage in vitro and ex vivo. Biochim Biophys Acta 2000; 1487 (2-3):113–127.

Kumar SS, Shankar B, Sainis KB. Effect of chlorophyllin against oxidative stress in splenic lymphocytes in vitro and in vivo. Biochim Biophys Acta 2004 72(2):100–111.

Fahey JW, Stephenson KK, Dinkova-Kostova AT, Egner PA, Kensler TW, Talalay P. Chlorophyll, chlorophyllin and related tetrapyrroles are significant inducers of mammalian phase 2 cytoprotective genes. Carcinogenesis 2005; 26(7):1247–1255.

Hsu CY, Yang C M, Chen C M, Chao P Y, Hu S P. Effects of chlorophyll-related compounds on hydrogen peroxide induced DNA damage within human lymphocytes. J Agric Food Chem 2005; 53 (7):2746–50.




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