INFLUENCE OF METHYL AND ISOPROPYL N-METHYL ANTHRANILATES ON CARBON TETRACHLORIDE-INDUCED CHANGES IN RAT LIVER AND KIDNEY MORPHOLOGY AND FUNCTION

Abstract

The aim of the present study was to examine potential protective effects of methyl N-methylanthranilate (M) and isopropyl N-methylanthranilate (I) in a rat model of acute intoxication with carbon tetrachloride (CCl₄) by tracking the changes in liver and kidney tissues morphology and function. Serum transaminases, bilirubin, creatinine and urea in serum were significantly elevated in CCl₄ alone treated animals. A pretreatment with M and I prior to the administration of CCl₄ significantly prevented the increase of serum levels of liver damage markers, whereas only M prevented decreased kidney function. The histopathological evaluation of the liver and kidney of the animals also revealed that M and I reduced the incidence of both liver and kidney lesions. Our experiments showed that both M and I possess protective effect in CCl₄-induced liver and kidney damage in rats. The results are of interest due to the presence of natural or synthetic M in the human diet.