EFFECTS OF CADMIUM, AN ENVIRONMENTAL AND OCCUPATIONAL POLLUTANT, ON LIPID PEROXIDATION IN RAT PANCREATIC TISSUE

Jasmina M. Jovanović Mirković, Gordana M. Kocić, Ružica S. Nikolić

DOI Number
https://doi.org/10.22190/FUWLEP1802167J
First page
167
Last page
173

Abstract


Technological development, industrialization and economic development have improved living standards, but also increased toxic metal emissions in the living and working environment. The aim of this study is the monitoring of lipid peroxidation in case of acute intoxication by heavy metal cadmium and the protective role of α-lipoic acid. In this study, we used healthy albino Wistar female rats, two or three months old. Based on the results obtained in this study, we note that cadmium-induced intoxication increases the level of malondialdehyde (MDA) in the pancreatic tissue homogenate. MDA is a direct indication of lipid peroxidation. Alpha-lipoic acid suggests reduction and correction of the toxic effect of cadmium after its exposure. 


Keywords

Heavy metals, cadmium, α-lipoic acid, malondialdehyde, lipid peroxidation

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REFERENCE:

Alina, M., Azrina, A., Mohd Yunus, A.S., Mohd Zakiuddin, S., Mohd Izuan Effendi, H., Muhammad Rizal, R., (2012), Heavy metals (mercury, arsenic, cadmium, plumbum) in selected marine fish and shellfish along the Straits of Malacca. Int Food Res J., 19(1), 135-140.

Han, J.X., Shang, Q., Du, Y., (2009), Effect of environmental cadmium pollution on human health. Health, 1(3), 159-166.

Lauwerys, R., (1979), Cadmium in man, The chemistry, biochemistry and biology of cadmium. North Holland Biomed. Press, Elseiver, 433-453.

Nikolić, R., Jovanović, J., Kocić, G., Cvetković, T., Stojanović, S., Anđelković, T., Krstić, N., (2011), Monitoring the effects of exposure to lead and cadmium in working and living environment through standard biochemical blood parameters and liver endonucleases activity. Hemijska industrija, 65(4), 403-409.

Brzoska, M., Moniuszko Jakoniuk, J., (1997), Calcium deficiency as on the risk factors for osteoporosis. Post. Hig. Med. Dosw. 51, 55-74.

Friberg, L., Nordberg, GF. Vouk, VB., (1986), In: Handbook on the Toxicology of Metals, Elsevier, Amsterdam, New York, Oxford, 521-531.

Ogoshi, K., Yukuo, N. Moriyama, T., (1992), Decrease in bone strength of cadmium-treated young and old rats. Arch. Toxicol., 66, 315-320.

Bernard A., (2008), Cadmium & its adverse effects on human health. Indian J Med Res., 128(4), 557-64.

Chakraborty, S., Dutta, A.R., Sural, S., Gupta, D., Sen, S., (2013), Ailing bones and failing kidneys: a case of chronic cadmium toxicity. Ann Clin Biochem., 50(5), 492-495.

Sreejayan, N., Von Ritter, C., (1999), Lipid peroxidation in bile: the role of hydrophobic bile acids and the effect on biliary epithelial cell function. Patophysiology, 5(4), 225-32.

Yiin, SJ., Lin, TH., (1995), Lead-catalyzed peroxidation of essential unsaturated fatty acid. Biol. Trace Elem., 50, 167-172.

Humad, S., Yarlong, E., Clapper, M., Skosez, JL., (1988), Free Radic. Res. Comm., 5, 101-106.

Weity, YW., Bimbaum, AJ., Sobotka, PA., Yarling, EJ., Skosez, JL., (1991), Lancet, 337, 933-935.

Toshiniwal, PK., Yarling, EJ., (1992), Neurochem. Res., 17, 205-207.

Drury, JA., Nycyk, JA. and Cooke, RW., (1997), Free Radic. Biol. Med., 22, 895-900.

Arterbery, VE., Prayer, WA., Jiang, L., Sehnert, SS., Foster, WM., Abrams, RA., Williams, JR., Wharam, MD. and Risby, TH., (1994), Free Radic. Biol. Med. 17, 569-576.

Sedghi, S., Keshavarzian, A., Klamut, M., Elznhamer, D., Zarling, EJ., (1994), Am. J. Gastroenterol., 89, 2217-2221.

Reed, LJ., DeBusk, BG., Gunsalus, IC., (1951), Crystaline -lipoic acid: a catalytic agent associated with pyruvate dehydrogenase. Science, 114, 93-94.

Harris, RA., Joshi, M., Jeoung, NH. and Obayashi, M., (2005), Overview of the molecular and biochemical basis of branched-chain amino acid catabolism. J. Nutr., 135(6), 1527S-1530S.

Kocić, G., Pavlović, D., Pavlović, R., Nikolić, G., Cvetković, T., Stojanović, I., Kocić, R., (2004), Sodium nitroprusside and preoxynitrite effect on hepatic DNases: An in vitro and in vivo study. Comp. Hepatol., 3(6), 1-9.

Kocić, G., Vlahović, P., Pavlović, D., Kocić, R., Jevtović, T., Cvetković, T., Stojanović, I., (1998), The possible importance of the cation-binding site for the oxidative modification of liver 5`- nucleotidase. Arch. Physiol. Biochem., 106, 91-99.

Andreeva, L., Kozhemiakin, L. and Kishkun, A., (1988), Modification of the method of determining lipid peroxidation in a test using thiobarbituric acid. Laboratornoe delo, 11, 41-43.

Halliwell, B.I. and Gutteridge, J.M.C., (1985), Lipid peroxidation a radical chain reaction, U, Free radicals an biology and medicine. Oxford, Clarendom Press, 193-189.

Slater, T.F., (1984), Free radical mechanism in tissue injury. Biochem. J., 222, 1-15.

Farber, J.L., Kyle, M.E. and Coleman, J.B., (1990), Lab. Invest., 62, 670-679.

Halliwell, B.I. and Guteridge, J.M.C., (1984), Lance, 23, 1396-1397.

Đorđević, V., Pavlović, D., Kocić, G., (2000), Biochemistry of free radicals, Niš, Sirius Print, (1).

Nikolson, G.L., (1978), Biochem. Biophys. Acta, 457, 57-108.

Bellomio, G. and Orrenius, S., (1985), Hepatology, 5, 876-882.

Thomas C.E. and Reed, D.J., (1989), Hepatology, 10, 375-384.

Sreejayan, N. and Von Ritter, C., (1999), Lipid peroxidation in bile: the role of hydrophobic bile acids and the effect on biliary epithelial cell function. Patophysiology, 5(4), 225-32.

Jacob, S., Streeper, R.S., Fogt, D.L., Hokama, J.Y., Tritschler, H.J., Dietze, G.J., Henriksen, E.J., (1996), The antioxidant α-lipoic acid enhances insulin-stimulated glucose metabolism in insulin-resistant rat skeletal muscle. Diabetes, 45(8), 1024-1029.

Stoyanovsky, D.A., Tyurina, Y.Y., Tyurin, Y.Y., Anand. D., Mandavia, D.N., Gius, D., Ivanova, J., Pitt, B., Billiar, T.R., Kagan, V.E., (2005), Thioredoxin and lipoic acid catalyze the denitrosation of low molecular weight and protein S-nitrosothiols. J. Am. Chem. Soc., 16(45), 15815-15823.

Da Ros, R., Assaloni, R. and Ceriello, A., (2005), Molecular targets of diabetic vascular complications and potential new drugs. Curr Drug Targets, 6(4), 503-509.

Yoshikawa, T., Toyokuni, S., Yamamoto, Y., Naito, Y., (2000), Free Radicals in Chemestry Biology and Medicine, OICE International, Sain Lucia, London.

Nair, V., Cooper, C.S., Vieti D.E. and Turner, G.A., (1986), Lipids, 21, 6-10.

Andreeva, L., Kozhemiakin, L. and Kishkun, A., (1988), Modification of the method of determining lipid peroxidation in a test using thiobarbituric acid. Laboratornoe delo, 11, 41-43.




DOI: https://doi.org/10.22190/FUWLEP1802167J

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